The synthesis of both 3,5-Disubstituted ∆2-isoxazolines began with the following steps: 1.P-anisaldehyde was reacted with allylmagnesium chloride in what is known as a Grignard reaction. This reaction essentially lengthened the carbon chain of the p-anisaldehyde. This branch of the carbon chain will eventually connect the isoxazole ring to the rest of the molecule. The product formed by this reaction was 1-(4-Methoxyphenyl)-3-buten-1-ol. 2.1-(4-Methoxyphenyl)-3-buten-1-ol was then reacted with pyridiniumchlorochromate (PCC) in a type of reaction called oxidation. In this reaction, the PCC was the oxidizer, which essentially acted by removing a hydrogen from the 1-(4-Methoxyphenyl)-3-buten-1-ol. The end product was 1-(4-Methoxyphenyl)-3-buten-1-one (the only difference being the missing hydrogen. 3.The newly-made 1-(4-Methoxyphenyl)-3-buten-1-one was reacted with hydroxylamine hydrochloride in order to form a product called an oxime. This oxime will be the starting material from which both isoxazolines will be formed. The oxime made was (IE)-N-Hydroxy-1-(4-methoxyphenyl)-3-buten-1-imine.
The final synthesis of the 3,5-Disubstituted ∆2-isoxazolines was made through separate cyclization reactions, each involving different metalloids to form the different isoxazolines: •(IE)-N-Hydroxy-1-(4-methoxyphenyl)-3-buten-1-imine was then reacted with nickel (II) chloride for on reaction, and palladium (II) chloride for a separate reaction, thus forming two 3,5-Disubstituted ∆2-isoxazolines, one nickel-based, the other palladium-based.