•The synthesis for the nickel-based 3,5-Disubstituted ∆2-isoxazoline was only partially successful. This failure could be because the nickel is not strong enough to cyclize through the reaction completely, or because it was not strong enough keep the form of the isoxazole ring. Of course, the poor results could also be due simply to human error, a factor that is always present in research. •The synthesis for the palladium-based 3,5-Disubstituted ∆2-isoxazoline, on the other hand, proved to be fairly successful and pure. However, the proton NMR taken of the palladium-based 3,5-Disubstituted ∆2-isoxazoline suggested that the palladium derivative fell off of the carbon chain. •The success of the palladium-based cyclization could be due to a number of reasons: •Palladium could be better at cyclizing than nickel •Palladium could be stronger at holding the structure of the isoxazole ring •Palladium holds its electrons better that the nickel